Lipid nanoparticle (LNP) engineering

Solutions for assembly, stability, tropism, functionalization & more 

Context
Lipid Nanoparticle-Mediated Delivery of mRNA Therapeutics and Vaccines
Swingle et al 2021

Lipid Nanoparticles (LNPs) for RNA delivery

Lipid nanoparticles (LNPs) have emerged as a powerful delivery platform for RNA therapies. Their effectiveness hinges on precise design and formulation, which dictate critical biophysical properties such as stability, biodistribution, and cellular uptake. However, optimizing LNPs for therapeutic success requires addressing key challenges such as:

Engineering ionizable lipids for stability and efficient delivery.

Enhancing tissue-targeted specificity while minimizing off-target effects.

Mitigating immunogenicity to reduce inflammatory responses and anti-PEG immunity.

Solutions

Solutions for LNP engineering

01

Screening ionizable lipids for optimal transfection efficiency in target tissue/cell type

02

Deciphering LNP assembly and interior morphology

03

Optimizing mRNA encapsulation and structural characterization

04

Regulating LNP size and polydispersity

05

Enhancing surface functionalization with monoclonal antibodies (mAbs)

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Screening ionizable lipid libraries for tropism

AI-powered screening

AI models to predict and rank formulations on transfection efficiency for a target tissue/cell type.

MD simulation of LNP fusion

Multi-microsecond simulation of LNP-endosomal membrane fusion, with enhanced molecular dynamics (MD).

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